Immune Dysregulation
Research into immune-cell activity and inflammatory signaling informs our therapeutic hypothesis in ALS.
Understanding Immune Biology in ALS
Research into the interplay among immune-cell activity, inflammatory signaling, and genomic findings informs a testable hypothesis for ALS.
A Biological Framework for Patient Selection and Therapeutic Research
We are investigating how differences in immune function may inform patient selection and therapeutic development.
Biomarker Strategy
Exploratory immune and genomic findings may help identify a biologically defined patient subgroup. This strategy requires validation.
Therapeutic Approach
Our investigational combination aims to address complementary inflammatory pathways while supporting cellular redox balance.
Two Immune Populations Under Investigation
NK Immuno T examines how Natural Killer cells and cytotoxic CD8+ T cells may contribute to disease-associated immune dysregulation in ALS. Their phenotype, functional activation and cytokine output can help inform a biomarker-guided research framework.
Explore the research library →A Patient Story That Shaped Our Research
A longitudinal twin study helped frame questions about immune function in ALS. Researchers followed a person living with ALS and his unaffected identical twin, examining immune-cell populations and activity over time.
The observed differences helped generate hypotheses about immune dysregulation that inform continuing research.
One case can generate a research question. Larger studies are needed to establish how broadly the findings apply.
Read the study and DOI 10.1615/CritRevImmunol.2023047233 ↗